Atherosclerosis

Reports outline atherosclerosis study findings from Shandong University

Published in Gene Therapy Weekly, September 18th, 2008

"The purpose of this study was to test the hypothesis that ACE2 overexpression may enhance atherosclerotic plaque stability by antagonizing ACE activity and converting angiotensin II to angiotensin 1-7. Atherosclerotic plaques were induced in the abdominal aorta of 114 rabbits by endothelial injury and atherogenic diet," researchers in Jinan, People's Republic of China report.

"Gene therapy was performed in group A at week 4 and in group B at week 12, respectively. Each group of rabbits were randomly divided into 3 subgroups which received, respectively, a recombinant ACE2 expressing vector (AdACE2), a control vector AdEGFP and AdACE2+A779, an antagonist of angiotensin...

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Source: Gene Therapy Weekly (2008-09-18)

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