Gene Therapy

Scientists at University of London publish new data on gene therapy

Published in Gene Therapy Weekly, September 18th, 2008

According to a study from London, the United Kingdom, "B-lymphocytes play a key role in the pathogenesis of many immune-mediated diseases, such as autoimmune and atopic diseases. Therefore, targeting B-lymphocytes provides a rationale for refining strategies to treat such diseases for long-term clinical benefits and minimal side effects."

"In this study we describe a protocol for repopulating irradiated mice with B-lymphocytes engineered for restricted expression of transgenes using haematopoietic stem cells. A self-inactivating lentiviral vector, which encodes enhanced green fluorescence protein (EGFP) from the spleen focus-forming virus (SFFV) promoter, was used to...

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Source: Gene Therapy Weekly (2008-09-18)

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