Breast Cancer
Scientists at University of Alabama describe research in breast cancer
Published in Gene Therapy Weekly, September 18th, 2008
According to a study from the United States, "Overexpression of transforming growth factor (TGF)-beta has been implicated in promoting immune suppression, tumor angiogenesis, tumor cell migration, and invasion in many cancers, including carcinoma of the breast. Thus, targeted down-regulation of TGF-beta 1 expression in breast cancer in situ and determination of its implications would provide new treatment approaches for disease management."
"Small interfering RNA constructs targeting TGF-beta 1 were validated and used to develop clonal derivatives of the metastatic breast cancer cell line MDA-MB-435. The cells were used in several in vitro analyses, including migration,...
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Source: Gene Therapy Weekly (2008-09-18)
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