Cancer Gene Therapy

New cancer gene therapy research from National Taiwan University, Medical Department discussed

Published in Gene Therapy Weekly, September 18th, 2008

According to recent research from Taipei, Taiwan, "A novel method for generating an antigen-specific cancer vaccine and immunotherapy has emerged using a DNA vaccine. However, antigen-presenting cells (APCs) have a limited life span, which hinders their long-term ability to prime antigen-specific T cells."

"Connective tissue growth factor (CTGF) has a role in cell survival. This study explored the intradermal administration of DNA encoding CTGF with a model tumor antigen, human papilloma virus type 16 E7. Mice vaccinated with CTGF/E7 DNA exhibited a dramatic increase in E7-specific CD4(+) and CD8(+) T-cell precursors. They also showed an impressive antitumor effect...

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Source: Gene Therapy Weekly (2008-09-18)

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