RNA Research

New findings from University of Dusseldorf describe advances in RNA research

Published in Gene Therapy Weekly, September 25th, 2008

According to recent research from Dusseldorf, Germany, "The p57kip2 gene encodes a member of the cyclin-dependent kinase inhibitor family, proteins known to block G(1)/S transition during the mammalian cell cycle. We observed that expression of p57kip2 in Schwann cells of the developing and injured adult peripheral nervous system is dynamically regulated."

"Using gene knockdown by means of vector-based RNA interference in cultured primary Schwann cells we found that reduced levels of p57kip2 lead to cell cycle exit, actin filament stabilization, altered cell morphology and growth, and down-regulation of promyelinating markers as well as induction of myelin genes and...

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Source: Gene Therapy Weekly (2008-09-25)

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