Gene Therapy

Research on gene therapy described by scientists at Mayo Clinic, Medical Department

Published in Gene Therapy Weekly, September 25th, 2008

According to recent research from the United States, "There are several roadblocks that hinder systemic delivery of oncolytic viruses to the sites of metastatic disease. These include the tumor vasculature, which provides a physical barrier to tumor-specific virus extravasation."

"Although interleukin-2 (IL-2) has been used in antitumor therapy, it is associated with endothelial cell injury, leading to vascular leak syndrome (VLS). Here, we demonstrate that IL-2-mediated VLS, accentuated by depletion of regulatory T cells (Treg), facilitates localization of intravenously (IV) delivered oncolytic virus into established tumors in immune-competent mice. IL-2, in...

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Source: Gene Therapy Weekly (2008-09-25)

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