World Journal of Gastroenterology
LOH analysis on 4q in sporadic colorectal carcinoma
Published in Gene Therapy Weekly, October 9th, 2008
Thirteen fluorescent labeled polymorphic microsatellite markers were analyzed in 83 cases of colorectal carcinoma and matched normal tissue DNA by polymerase chain reaction (PCR). PCR products were eletrophoresed on an ABI 377 DNA sequencer. Genescan 3.7 and Genotype 3.7 software were used for loss of heterozygosity (LOH) scanning and analysis. Compared with clinicopathological features, significant relationship was observed between LOH frequencies on D4S3018 locus. In tumor larger than 5 cm in diameter, LOH frequency was significantly higher than that less than 5 cm (56% vs13.79%, P = 0.01). On D4S1534 locus, LOH was significantly associated with liver metastasis (80% vs 17.25%, P =...
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Source: Gene Therapy Weekly (2008-10-09)
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