Allergies

Study data from National Institute of Allergy and Infectious Diseases update understanding of allergies

Published in Gene Therapy Weekly, October 9th, 2008

"Recovery from Friend virus 3 ( Rfv3) is a single autosomal gene encoding a resistance trait that influences retroviral neutralizing antibody responses and viremia. Despite extensive research for 30 years, the molecular identity of Rfv3 has remained elusive," investigators in the United States report.

"Here, we demonstrate that Rfv3 is encoded by Apobec3. Apobec3 maps to the same chromosome region as Rfv3 and has broad inhibitory activity against retroviruses, including HIV. Not only did genetic inactivation of Apobec3 convert Rfv3- resistant mice to a susceptible phenotype, but Apobec3 was also found to be naturally disabled by aberrant messenger RNA splicing in Rfv3-...

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Source: Gene Therapy Weekly (2008-10-09)

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