Published in Gene Therapy Weekly, October 16th, 2008
"We studied in vitro and in vivo effects of saturated and polyunsaturated acids on insulin secretion, insulin signaling, and expression of genes involved in beta-cell functions. Pancreatic islets isolated from C57BL/6 control and SREBP-1-null mice and adenoviral gene delivery or knockdown systems of related genes were used. Incubation of C57BL/6 islets with palmitate caused inhibition of both glucose- and...
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