Antibiotics

New findings from Harvard University describe advances in antibiotics

Published in Gene Therapy Weekly, October 16th, 2008

"Pepticloglycan glycosyltransferases (PGTs), enzymes that catalyze the formation of the glycan chains of the bacterial cell wall, have tremendous potential as antibiotic targets. The moenomycins, a potent family of natural product antibiotics, are the only known active site inhibitors of the PGTs and serve as blueprints for the structure-based design of new antibacteriats," researchers in the United States report.

"A 2.8 angstrom structure of a Staphylococcus aureus PGT with moenomycin A bound in the active site appeared recently, potentially providing insight into substrate binding; however, the protein-ligand contacts were not analyzed in detail and the implications...

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Source: Gene Therapy Weekly (2008-10-16)

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