Enzyme Research
New findings in enzyme research described from Charite University
Published in Gene Therapy Weekly, October 16th, 2008
Current study results from the report, 'Requirement of an intermediate gene expression for biphasic ERK1/2 activation in thrombin-stimulated vascular smooth muscle cells,' have been published. "The expression of contractile proteins in vascular smooth muscle cells is controlled by still poorly defined mechanisms. A thrombin-inducible expression of smooth muscle-specific alpha-actin and myosin heavy chain requires transactivation of the epidermal growth factor (EGF) receptor and a biphasic activation of ERK1/2," scientists in Berlin, Germany report.
"Here we demonstrate that the sustained second phase of ERK1/2 phosphorylation requires de novo RNA and protein synthesis....
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Source: Gene Therapy Weekly (2008-10-16)
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