Nasopharyngeal Carcinoma
Research on nasopharyngeal carcinoma detailed by W. Ayadi and co-authors
Published in Gene Therapy Weekly, October 23rd, 2008
"Aberrant methylation of tumor suppressor gene (TSG) promoters has been extensively investigated in nasopharyngeal carcinomas (NPC) from South East Asia but not from North Africa. The methylation status of p16, deleted in lung and esophageal cancer (DLEC1), zinc finger, MYND-type containing 10 (BLU) and E-cadherin gene promoters was investigated in 44 Tunisian NPC biopsies and three NPC xenografts, by methylation-specific PCR (MSP) combined with a quantitative assessment of some of the samples," investigators in Sfax, Tunisia report.
"The frequencies of aberrant promoter methylation were similar to previous figures reported for Asian series: p16 27/44 (65%), DLEC1 38/44...
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Source: Gene Therapy Weekly (2008-10-23)
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