Prostate Cancer

New prostate cancer research from University of Kansas discussed

Published in Gene Therapy Weekly, October 23rd, 2008

According to a study from the United States, "Phosphoinositide 3-OH kinases (PI3Ks) are a group of major intracellular signaling molecules. In our previous study, we found that inhibition of PI3K activity suppressed the androgen receptor (AR)-mediated gene expression in prostate cancer cells."

"The AR has been considered as a critical determinant for the development and progression of human prostate cancers. In this study, we sought to identify the PI3K isoforms involved in AR transactivation. Using a gene-specific small interference RNA (siRNA) approach, we determined that the regulatory isoform p85 alpha and the catalytic isoform p110 beta, but not p110 alpha, were...

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Source: Gene Therapy Weekly (2008-10-23)

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