Gene Therapy

Research from Okayama University provides new data on gene therapy

Published in Gene Therapy Weekly, October 23rd, 2008

According to a study from Okayama, Japan, "Gene therapy and virotherapy are one of the approaches used to treat malignant pleural mesothelioma. To improve the efficiency of targeting malignant mesothelioma cells-, we designed a novel system using the promoter of the CREBBP/EP300 inhibitory protein 1 (CRI1), a gene specifically expressed in malignant pleural mesothelioma."

"Four tandem repeats of the CRI1 promoter (CRI1(-138) (4x)) caused significantly high promoter activity in malignant pleural mesothelioma cells but little promoter activity in normal mesothelial cells and normal fibroblasts. The recombinant adenoviral vector expressing proapoptotic BH3-interacting...

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Source: Gene Therapy Weekly (2008-10-23)

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