Angiogenesis

New findings from Howard University in the area of angiogenesis published

Published in Gene Therapy Weekly, October 23rd, 2008

"Tumor-associated macrophages (TAMs) secrete key modifiers of tumor progression and their modification has been proposed as a therapeutic strategy. Phenotypic changes that may render TAMs selectively vulnerable to anti-cancer agents were examined," researchers in the United States report.

"Gene arrays, reverse transcription-polymerase chain reaction and Western blotting were used to study inflammation- and angiogenesis-related gene expression in co-cultured breast cancer cells and macrophages and to determine how their interactions were affected by tamoxifen and aspirin. MCF-7 (mammary adenocarcinoma) cells down-regulated macrophage migration inhibitory factor (MIF),...

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Source: Gene Therapy Weekly (2008-10-23)

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