Life Sciences
New life sciences study findings recently were reported by P. Stmad and co-researchers
Published in Gene Therapy Weekly, October 23rd, 2008
"The cytoplasmic hepatocyte inclusions, Mallory-Denk bodies (MDBs), are characteristic of several liver disorders, including alcoholic and nonalcoholic steatohepatitis. In mice, MDBs can be induced by long-term feeding with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) for 3 to 4 months or rapidly reformed in DDC-induced then recovered mice by DDC refeeding or exposure to a wide range of toxins for only 5 to 7 days," scientists writing in the journal Hepatology report.
"The molecular basis for such a rapid reinduction of MDBs is unknown. We hypothesized that protein changes retained after DDC priming contribute to the rapid MDB reappearance and associate with...
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Source: Gene Therapy Weekly (2008-10-23)
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