RNA Research

Researchers from New York University describe findings in RNA research

Published in Gene Therapy Weekly, October 30th, 2008

According to a study from the United States, "Huntington's disease is a dominant autosomal neurodegenerative disorder caused by an expansion of polyglutamines in the huntingtin (Htt) protein, whose cellular function remains controversial. To gain insight into Htt function, we purified epitope-tagged Htt and identified Argonaute as associated proteins."

"Colocalization studies demonstrated Htt and Agog to be present in P bodies, and depletion of Htt showed compromised RNA-mediated gene silencing. Mouse striatal cells expressing mutant Htt showed fewer P bodies and reduced reporter gene silencing activity compared with wild-type counterparts," wrote J.N. Savas and...

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Source: Gene Therapy Weekly (2008-10-30)

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