Gene Therapy

Study data from Brown University provide new insights into gene therapy

Published in Gene Therapy Weekly, October 30th, 2008

"Malignant pleural mesothelioma (MPM) is a rapidly fatal tumor with increasing incidence worldwide responsible for many thousands of deaths annually. Although there is a clear link between exposure to asbestos and mesothelioma, and asbestos is known to be both clastogenic and cytotoxic to mesothelial cells, the mechanisms of causation of MPM remain largely unknown," scientists in the United States report.

"However, there is a rapidly emerging literature that describes inactivation of a diverse array of tumor suppressor genes (TSGs) via promoter DNA CpG methylation in MPM, although the etiology of these alterations remains unclear. We studied the relationships among...

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Source: Gene Therapy Weekly (2008-10-30)

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