Gene Therapy
Data from University of Cambridge advance knowledge in gene therapy
Published in Gene Therapy Weekly, November 6th, 2008
According to recent research from Cambridge, the United Kingdom, "Polyethyleneimine (PEI), a well-established nonviral transfection reagent, was combinatorially modified with varying proportions of methyl, benzyl, and n-dodecyl groups to create a library of 435 derivatized polymers. Screening of this library for transfection, DNA binding, and toxicity allows systematic correlation of the biological properties of our polymers to their derivatizations."
"Combinations of derivatizations bring about a 100-fold variation in transfection efficiency between library members. The best PEI derivatives exhibit increases in transfection efficiency of more than 80-fold over...
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Source: Gene Therapy Weekly (2008-11-06)
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