Angiogenesis

Data from State University of New York provide new insights into angiogenesis

Published in Gene Therapy Weekly, November 6th, 2008

According to recent research from the United States, "Angiogenesis is critical in normal development and in tumor growth. Experimentally, cyclosporine A (CyA) inhibits angiogenesis in an in vivo mouse model and an in vitro capillary tube model."

"The mechanisms behind its antiangiogenic effects are not well characterized. To determine which nuclear factor, if any, may be involved in the antiangiogenic effects of CyA, we performed a microarray analysis of human aortic endothelial cells (HAEC) subjected to CyA and another calcineurin inhibitor, FK 506. HAEC were divided into four groups: (1) HAEC incubated with CyA 2 mu g/mL; (2) HAEC incubated with CyA 10 mu g/mL; (3)...

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Source: Gene Therapy Weekly (2008-11-06)

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