Gene Therapy
Researchers from Meiji University, Department of Life Sciences report on findings in gene therapy
Published in Gene Therapy Weekly, November 13th, 2008
Research findings, 'Transcriptional co-factor CDCA4 participates in the regulation of JUN oncogene expression,' are discussed in a new report. "CDCA4, a member of the TRIP-Br transcriptional co-factor family, has been shown to possess a unique role in regulating the transcriptional activities of p53 as well as E2F1 transcription factors. In this study, we aimed to identify a pivotal transcriptional target gene regulated by CDCA4, so we suppressed CDCA4 expression by CDCA4-specific short interference RNA (siRNA) in HeLa cells, and then performed a DNA microarray analysis," scientists in Kawasaki, Japan report.
"Among the identified genes, we focused on JUN, 14-3-3eta,...
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Source: Gene Therapy Weekly (2008-11-13)
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