Physiology
Research on physiology detailed by scientists at Queen's University, Department of Physiology
Published in Gene Therapy Weekly, November 13th, 2008
New research, 'CaSR stimulates secretion of Wnt5a from colonic myofibroblasts to stimulate CDX2 and sucrase-isomaltase using Ror2 on intestinal epithelia,' is the subject of a report. "To understand whether extracellular calcium-sensing receptor (CaSR) expression on colonic myofibroblast cells (18Co) contributed to epithelial homeostasis, we activated the CaSR with 5 mM Ca(2+), screened by RT-PCR Wnt family members, and measured their secretion. Transcripts for Wnt 1, 2, 2b, 3a, 4, and 7a were either absent or unchanged whereas Wnt3 decreased and Wnt5a increased," researchers in Canada report.
"We assessed Wnt5a secretion by Western blot. High Ca(2+) (5 mM)...
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Source: Gene Therapy Weekly (2008-11-13)
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