Alzheimer Disease
Research data from University of Wisconsin update understanding of Alzheimer disease
Published in Gene Therapy Weekly, November 13th, 2008
"We have recently identified a new form of post-translational regulation of BACE1 (beta-site amyloid precursor protein (APP)-cleaving enzyme 1), a membrane protein that acts as the rate-limiting enzyme in the generation of the Alzheimer disease amyloid beta-peptide (A beta). Specifically, BACE1 is transiently acetylated on seven lysine residues in the lumen of the endoplasmic reticulum/endoplasmic reticulum-Golgi intermediate compartment (ER/ERGIC)," scientists in the United States report.
"The acetylated intermediates of the nascent protein are able to reach the Golgi apparatus, whereas the non-acetylated ones are retained and degraded in a post-ER compartment. Here,...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
Source: Gene Therapy Weekly (2008-11-13)
More Articles from Gene Therapy Weekly
- Adenovirus
Investigators at Tufts University, Medical Department target adenovirus - Allograft Nephropathy
Research conducted at Sichuan University has updated our knowledge about allograft nephropathy - Apoptosis
New apoptosis research has been reported by scientists at Dalhousie University - Apoptosis
New apoptosis study findings recently were published by researchers at Osaka University - Apoptosis
Scientists at University of Burgundy describe research in apoptosis - Applied Biosystems Inc.
Researchers from Applied Biosystems and the University of Ghent Demonstrate Effectiveness of Megaplex miRNA Profiling Tools on Small Samples - More from this issue of Gene Therapy Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
