Gene Therapy
Research from Ruhr University broadens understanding of gene therapy
Published in Gene Therapy Weekly, November 13th, 2008
"Here we report that miR-34a expression is silenced in several types of cancer due to aberrant CpG methylation of its promoter. 19 out of 24 (79.1%) primary prostate carcinomas displayed CpG methylation of the miR-34a promoter and concomitant loss of miR-34a expression. CpG methylation of the miR-34a promoter was also detected in breast (6/24; 25%), lung (7/24; 29.1%), colon (3/23; 13%), kidney (3/14; 21.4%), bladder (2/6; 33.3%) and pancreatic...
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Source: Gene Therapy Weekly (2008-11-13)
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