Life Sciences
Research from University of Alberta in the area of life sciences published
Published in Gene Therapy Weekly, November 27th, 2008
According to recent research from Edmonton, Canada, "F plasmid-mediated bacterial conjugation requires interactions between a relaxosome component, TraM, and the coupling protein TraD, a hexameric ring ATPase that forms the cytoplasmic face of the conjugative pore. Here we present the crystal structure of the C-terminal tail of TraD bound to the TraM tetramerization domain, the first structural evidence of relaxosome-coupling protein interactions."
"The structure reveals the TraD C-terminal peptide bound to each of four symmetry-related grooves on the surface of the TraM tetramer. Extensive protein-protein interactions were observed between the two proteins. Mutational...
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Source: Gene Therapy Weekly (2008-11-27)
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