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Salk Institute

Novel regulatory step during HIV replication

Published in Gene Therapy Weekly, December 4th, 2008

A previously unknown regulatory step during human immunodeficiency (HIV) replication provides a potentially valuable new target for HIV/AIDS therapy, report researchers at the Salk Institute for Biological Studies and the University of Wisconsin, Madison.

Their study, published in this week's early online edition of the Public Library of Science, PLoS Pathogens, describes a new biological function for sulfonation—a type of chemical modification—which ensures that viral genes can be expressed efficiently after HIV successfully integrated into the host genome.

"The early steps of HIV infection are highly dependent on cellular processes and represent a...

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