Neuroblastoma

Study data from Lund University update knowledge of neuroblastoma

Published in Gene Therapy Weekly, December 4th, 2008

According to a study from Malmo, Sweden, "The childhood cancer neuroblastoma arises in the developing sympathetic nervous system and is a genotypically and phenotypically heterogeneous disease. Prognostic markers of poor survival probability include amplification of the MYCN oncogene and an undifferentiated morphology."

"Whereas these features discriminate high- from low-risk patients with precision, identification of poor outcome low- and intermediate-risk patients is more challenging. in this study, we analyze two large neuroblastoma microarray datasets using a priori-defined gene expression signatures. We show that differential overexpression of Myc transcriptional...

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Source: Gene Therapy Weekly (2008-12-04)

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