Published in Gene Therapy Weekly, December 11th, 2008
"Immature B lymphoma cells that express Egr-1 message and protein constitutively are growth inhibited when Egr-1 is down-regulated by negative signals from BCR or by antisense oligonucleotides. To test the hypothesis that Egr-1 is important for B cell development, we examined B cells from primary and secondary lymphoid organs in Egr-l(-/-) mice. Marginal zone 13 cell development was arrested in these...
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