Antisense Technology

University of Kentucky details research in antisense technology

Published in Gene Therapy Weekly, December 11th, 2008

According to a study from the United States, "Egr-1 (early growth response gene-1) is an immediate early gene encoding a zinc finger motif-containing transcription factor. Upon cross-linking of BCR, mature B cells undergo proliferation with an increase in Egr-1 message."

"Immature B lymphoma cells that express Egr-1 message and protein constitutively are growth inhibited when Egr-1 is down-regulated by negative signals from BCR or by antisense oligonucleotides. To test the hypothesis that Egr-1 is important for B cell development, we examined B cells from primary and secondary lymphoid organs in Egr-l(-/-) mice. Marginal zone 13 cell development was arrested in these...

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Source: Gene Therapy Weekly (2008-12-11)

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