RNA Research

Research from University of Crete has provided new data on RNA research

Published in Gene Therapy Weekly, December 11th, 2008

According to recent research from Greece, "Cancer cells may evade immune surveillance as a result of defective antigen processing and presentation. In this study, we demonstrate that CD40 ligation overcomes this defect through the coordinated action of the transcription factors NF-kappa B and interferon regulatory factor 1 (IRF-1)."

"We show that unlike interferon signaling, which triggers the STAT1-mediated transcriptional activation of IRF-1, the ligation of CD40 in carcinomas induces the rapid upregulation of IRF-1 in a STAT1-independent but NF-kappa B-dependent manner. The transcriptional activation of IRF-1 is controlled largely by the recruitment of p65 (RelA)...

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Source: Gene Therapy Weekly (2008-12-11)

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