Published in Gene Therapy Weekly, December 11th, 2008
"We show that unlike interferon signaling, which triggers the STAT1-mediated transcriptional activation of IRF-1, the ligation of CD40 in carcinomas induces the rapid upregulation of IRF-1 in a STAT1-independent but NF-kappa B-dependent manner. The transcriptional activation of IRF-1 is controlled largely by the recruitment of p65 (RelA)...
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