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Gene Therapy

Report summarizes gene therapy study findings from University of Utah

Published in Gene Therapy Weekly, December 11th, 2008

"Adenosine deaminases that act on RNA (ADARs) are editing enzymes that convert adenosine to inosine in double-stranded RNA ( dsRNA). ADARs sometimes target codons so that a single mRNA yields multiple protein isoforms," scientists in the United States report.

"However, ADARs most often target noncoding regions of mRNAs, such as untranslated regions ( UTRs). To understand the function of extensive double-stranded 3' UTR structures, and the inosines within them, we monitored the fate of reporter and endogenous mRNAs that include structured 3' UTRs in wild-type Caenorhabditis elegans and in strains with mutations in the ADAR genes. In general, we saw little effect of...

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