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Cancer Gene Therapy
Studies from K.N. Barton and co-researchers yield new data on cancer gene therapy
December 18th, 2008
"To monitor noninvasively potentially therapeutic adenoviruses for cancer, we have developed a methodology based on the sodium iodide symporter (NIS). Men with clinically localized prostate cancer were administered an intraprostatic injection of a replication-competent adenovirus, Ad5-yCD/utTK(SR39)rep-hNIS, armed with two suicide genes and the NIS gene," scientists in the United States report. "NIS gene expression (GE) was imaged noninvasively by uptake of (NaTcO4)-Tc-99m in infected cells using single photon emission-computed tomography (SPECT). The investigational therapy was safe with 98% of the adverse events being grade 1 or 2. GE was detected in the prostate in...
Source: Gene Therapy Weekly (2008-12-18)
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