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Colon Cancer
Study findings from State University of New York broaden understanding of colon cancer
December 18th, 2008
"Anticancer agents act, at least in part, by inducing reactive oxygen and nitrogen species (RONS). We examined the redox effect on SW480 and HT-29 colon cancer cells of four anticancer compounds, arsenic trioxide, phosphoaspirin, phosphosulindac, and nitric oxide-donating aspirin (NO-ASA)," investigators in the United States report. "All compounds inhibited the growth of both cell lines (IC50, 10-90 mu mol/L) and induced RONS detected by a general RONS molecular probe. NO-ASA, which induced at least four individual RONS (NO, H2O2, superoxide anion, and peroxynitirte), induced apoptotic and necrotic cell death that was RONS-mediated (cell death paralleled RONS levels and...
Source: Gene Therapy Weekly (2008-12-18)
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