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DNA Research
Researchers from Northwestern University provide details of new studies and findings in the area of DNA research
December 18th, 2008
According to a study from the United States, "The transfection activity and the phase behavior of two novel cationic O-alkyl-phosphatidylcholines, 1,2-dioleoyl-sn-glycero-3-hexylphosphocholine (C6-DOPC) and 1,2-dierucoyl-sn-glycero-3-ethylphosphocholine (di22:1-EPC), have been examined with the aim of more completely understanding the mechanism of lipid-mediated DNA delivery. Both lipids form cubic phases: C6-DOPC in the entire temperature range from -10 to 90 degrees C, while di22:1-EPC exhibits an irreversible lamellar-cubic transition between 50 and 70 degrees C on heating." "The lipoplexes formed by C6-DOPC arrange into hexagonal phase, while the lipoplexes of...
Source: Gene Therapy Weekly (2008-12-18)
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