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DNA Vaccines
Research on DNA vaccines reported by scientists at Seoul National University
December 18th, 2008
According to a study from Seoul, South Korea, "Her-2/neu is a well-characterized tumor-associated antigen, the overexpression of which in human carcinomas correlates with a poor prognosis. Here, we evaluated Her-2/neu-specific humoral and cellular immune responses in immunized monkeys after immunization with nonreplicating adenovirus (AdHM) expressing the extracellular and transmembrane domain of human Her-2/neu (HM) and/or naked DNA vaccine (pHM-hGM-CSF) expressing human granulocyte-macrophage colony-stimulating factor together with HM." "Priming of monkeys with AdHM generated Her-2/neu-specific longlasting antibody production. Furthermore, these Her-2/neu-specific...
Source: Gene Therapy Weekly (2008-12-18)
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