Down Syndrome
Research from J. Ortizabalia and co-researchers provides new data on Down syndrome
Published in Gene Therapy Weekly, December 18th, 2008
"Genetic-dissection studies carried out with Down syndrome (DS) murine models point to the critical contribution of Dyrk] A overexpression to the motor abnormalities and cognitive deficits displayed in DS individuals. In the present study we have used a murine model overexpressing Dyrk1A (TgDyrk1A mice) to evaluate whether functional CNS defects could be corrected with an inhibitory RNA against Dyrk]A, delivered by bilateral intrastriatal injections of adeno-associated virus type 2 (AAVshDyrk1A)," investigators in Barcelona, Spain report.
"We report that AAVshDyrk1A efficiently transduced HEK293 cells and primary neuronal cultures, triggering the specific inhibition of...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
Source: Gene Therapy Weekly (2008-12-18)
More Articles from Gene Therapy Weekly
- Artificial Chromosomes
Studies from Royal Children's Hospital provide new data on artificial chromosomes - Bladder Cancer
New bladder cancer research from University of California discussed - Brain Cancer
Studies conducted at Harvard University, Medical Department on brain cancer recently published - Breast Cancer
New breast cancer study results reported from P.E. Corsino et al - Breast Cancer
Report summarizes breast cancer study findings from D.O. Croci and co-researchers - Breast Cancer
Reports summarize breast cancer study results from University of Lille - More from this issue of Gene Therapy Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
