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Gene Therapy
Findings from E. Garciaaragoncillo and co-authors provide new insights into gene therapy
December 18th, 2008
"The molecular hallmark of the Ewing's family of tumors is the presence of balanced chromosomal translocations, leading to the formation of chimerical transcription factors (that is, EWS/FLI1) that play a pivotal role in the pathogenesis of Ewing's tumors by deregulating gene expression. We have recently demonstrated that DAX1 (NR0B1), an orphan nuclear receptor that was not previously implicated in cancer, is induced by the EWS/FLI1 oncoprotein and is highly expressed in Ewing's tumors, suggesting that DAX1 is a biologically relevant target of EWS/FLI1-mediated oncogenesis," scientists in Madrid, Spain report. "In this study we demonstrate that DAX1 is a direct...
Source: Gene Therapy Weekly (2008-12-18)
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