Gene Therapy
Reports from Seoul National University highlight recent research in gene therapy
Published in Gene Therapy Weekly, December 18th, 2008
According to recent research from Seoul, South Korea, "A recombinant La Sota strain (KBNP-C4152R2L) in which fusion (F) and hemagglutinin-neuraminidase (HN) genes were replaced with those of a contemporary genotype VIId virus, KBNP-4152, has been developed. To attenuate the virulence of the recombinant strain, the F cleavage motif was mutated from (112)RRQKR(116) to (112)GRQAR(116), and to reduce pathogenic instability, a codon which does not allow changes to basic amino acids by single point mutation was inserted at codon 115."
"In addition a six-nucleotide sequence was inserted into the intergenic region between matrix protein and F genes for attenuation without...
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Source: Gene Therapy Weekly (2008-12-18)
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