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Gene Therapy
Reports from Seoul National University highlight recent research in gene therapy
December 18th, 2008
According to recent research from Seoul, South Korea, "A recombinant La Sota strain (KBNP-C4152R2L) in which fusion (F) and hemagglutinin-neuraminidase (HN) genes were replaced with those of a contemporary genotype VIId virus, KBNP-4152, has been developed. To attenuate the virulence of the recombinant strain, the F cleavage motif was mutated from (112)RRQKR(116) to (112)GRQAR(116), and to reduce pathogenic instability, a codon which does not allow changes to basic amino acids by single point mutation was inserted at codon 115." "In addition a six-nucleotide sequence was inserted into the intergenic region between matrix protein and F genes for attenuation without...
Source: Gene Therapy Weekly (2008-12-18)
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