Gene Therapy Weekly
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Gene Therapy
Reports summarize gene therapy research from Ewha Womans University
December 18th, 2008
"Epothilones, produced from the myxobacterium Sorangium cellulosum, are potential anticancer agents that stabilize microtubules in a similar manner to paclitaxel. The entire epothilone biosynthetic gene cluster was heterologously expressed in an engineered strain of Streptomyces venezuelae bearing a deletion of pikromycin polyketide synthase gene cluster," scientists in Seoul, South Korea report. "The resulting strains produced approximately 0.1 mu g/l of epothilone B as a sole product after 4 days cultivation. Deletion of an epoF encoding the cytochrome P450 epoxidase gave rise to a mutant that selectively produces 0.4 mu g/l of epothilone D. To increase the production...
Source: Gene Therapy Weekly (2008-12-18)
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