Gene Therapy Weekly
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Gene Therapy
Reports summarize gene therapy study results from D. Guo and co-researchers
December 18th, 2008
"hHSS (human hepatic stimulator substance) stimulates hepatocyte growth. To understand the mechanism controlling hHSS expression, we analysed the proximal promoter activity and identified two regulatory regions (-212/-192 and -152/-132) that were important for transcription in HepG2cells," researchers in Beijing, People's Republic of China report. "Using the luciferase reporter assay, gel-shift experiments and Chip (chromatin immunoprecipitation), we found that the transcription factors HNF4 alpha (hepatocyte nuclear factor 4 alpha) and Sp1 (stimulating protein-1) were essential for hHSS promoter activity and Could directly bind to regions -209/-204 and -152/-145...
Source: Gene Therapy Weekly (2008-12-18)
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