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Gene Therapy
Research in the area of gene therapy reported from Tufts University
December 18th, 2008
"Oxidative stress contributes to the development of neurodegenerative diseases. DJ-1, a protein genetically linked to Parkinosn's disease (PD), has been implicated in oxidative stress defense and transcriptional regulation," scientists in the United States report. "However, it is unclear whether these two aspects of the DJ-1 function are connected. Here, we show that the inactivation of DJ-1 causes decreased expression of the human MnSOD. DJ-1 stimulates the activity of a master regulator of mitochondrial biogenesis and stress response, peroxisome proliferator-activated receptor-gamma co-activator 1 alpha (PGC-1 alpha), in the transcription of the MnSOD. Although DJ-1...
Source: Gene Therapy Weekly (2008-12-18)
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