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Gene Therapy
Research reports from Technical University provide new insights into gene therapy
December 18th, 2008
According to recent research from the United States, "Recent studies demonstrate that recombinant adeno-associated virus (rAAV)-based antigen loading of dendritic cells (DCs) generates in vitro, significant and rapid cytotoxic T-lymphocyte (CTL) responses against viral antigens. We used the rAAV system to induce specific CTLs against CVM antigens for the development of cytomegalovirus HCMV) gene therapy." "As an extension of the versatility of the rAAV system, we incorporated immediate-early I (IEI), expressed in HCMV. Our rAAV vector induced a strong stimulation of CTLs directed against the HCMV antigen IEI. We then investigated the efficiency of the CTLs in killing...
Source: Gene Therapy Weekly (2008-12-18)
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