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Gene Therapy
Scientists at State University of New York publish research in gene therapy
December 18th, 2008
According to a study from the United States, "TAL (transaldolase) was originally described in the yeast as an enzyme of the PPP (pentose phosphate pathway). However, certain organisms and mammalian tissues lack TAL, and the overall reason for its existence is unclear." "Recently, deletion of Ser(171). (TAL Delta S171) was found in five patients causing inactivation, proteasome-mediated degradation and complete deficiency of TAL. In the present study, microarray and follow-up Western-blot, enzyme-activity and metabolic Studies of TAL Delta S 171 TD (TAL-deficient) lymphoblasts revealed co-ordinated changes in the expression of genes involved in the PPP, mitochondrial...
Source: Gene Therapy Weekly (2008-12-18)
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