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Gene Therapy
Studies from Juntendo University, Medical Department in the area of gene therapy published
December 18th, 2008
"Silencing of gene expression by small interfering RNAs (siRNAs) is rapidly becoming a powerful tool for genetic analysis and represents a potential strategy for therapeutic product development. However, there are no reports of systemic delivery of siRNAs for stable treatment except short hairpin RNAs (shRNAs)," investigators in Hongo, Japan report. "On the other hand, there are no reports of systemic delivery of siRNAs for transient treatment using liposome carriers and others. With regard to shRNAs, a report showed fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Therefore, we decided to use original siRNA microspheres instead of...
Source: Gene Therapy Weekly (2008-12-18)
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