Published in Gene Therapy Weekly, December 18th, 2008
"It is differentially expressed in the course of bone morphogenetic protein-2-triggered chondrocyte differentiation of pluripotent C3H10T1/2 cells. This expression is probably due to the activation of p204 gene by Cbfa1 and repression by Sox5 transcription factor. Cbfa1 and Sox5 bind to the 50-flanking regulatory region of p204 gene at their consensus binding elements. Overexpression of p204 accelerates chondrocyte...
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