Gene Therapy

Study results from New York University update understanding of gene therapy

Published in Gene Therapy Weekly, December 18th, 2008

"We reported earlier that an interferon-inducible p204 protein serves as a cofactor of Cbfa1 and promotes osteogenesis. Here we establish that p204 demonstrates prominent expression in growth plate chondrocytes," investigators in the United States report.

"It is differentially expressed in the course of bone morphogenetic protein-2-triggered chondrocyte differentiation of pluripotent C3H10T1/2 cells. This expression is probably due to the activation of p204 gene by Cbfa1 and repression by Sox5 transcription factor. Cbfa1 and Sox5 bind to the 50-flanking regulatory region of p204 gene at their consensus binding elements. Overexpression of p204 accelerates chondrocyte...

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Source: Gene Therapy Weekly (2008-12-18)

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