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Glioblastoma
New glioblastoma research has been reported by scientists at University of Dusseldorf
December 18th, 2008
According to recent research from Dusseldorf, Germany, "The N-myc downstream-regulated gene 2 (NDRG2) at 14q11.2 has been reported to be downregulated in glioblastoma, and NDRG2 overexpression represses glioblastoma cell proliferation in vitro (Deng et al., IntJ Cancer 2003;106;342-7). To further address the role of NDRG2 as a candidate tumor suppressor in human gliomas, we analyzed 67 astrocytic tumors (10 diffuse astrocytomas, 11 anaplastic astrocytomas, 34 primary glioblastomas and 12 secondary glioblastomas) for NDRG2 gene mutation, promoter methylation and expression at the mRNA and protein levels." "Using real-time reverse transcription PCR analysis, we found...
Source: Gene Therapy Weekly (2008-12-18)
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