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Hepatocellular Cancer
Studies from Kyoto University, Medical Department have provided new data on hepatocellular cancer
December 18th, 2008
According to recent research from Kyoto, Japan, "The parkin was first identified as a gene implicated in autosomal recessive juvenile Parkinsonism. Deregulation of the parkin gene, however, has been observed in various human cancers, suggesting that the parkin gene may be important in tumorigenesis." "To gain insight into the physiologic role of parkin, we generated parkin-/- mice lacking exon 3 of the parkin gene. We demonstrated here that parkin-/- mice had enhanced hepatocyte proliferation and developed macroscopic hepatic tumors with the characteristics of hepatocellular carcinoma. Microarray analyses revealed that parkin deficiency caused the alteration of gene...
Source: Gene Therapy Weekly (2008-12-18)
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