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Gene Therapy Weekly

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Lung Cancer



Data on lung cancer detailed by W.S. Chen and co-authors



December 18th, 2008

According to recent research from the United States, "Ambiguous roles of genotoxic anticancer therapeutic-induced NF-kappa B activation in regulating gene expression (activation or suppression) and apoptosis (anti- or pro-apoptosis) have recently been suggested. In order to clarify this controversy and determine the usefulness of NF-kappa B blockage for sensitizing anticancer therapy, we have systematically investigated the effect of distinct NF-kappa B-blocking approaches on lung cancer cells' responses to Adriamycin-induced cytotoxicity."

"The results show that Adriamycin-induced NF-kappa B activation functions as a transcriptional activator triggering the expression...


Source: Gene Therapy Weekly (2008-12-18)

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