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New findings in life sciences described from Johns Hopkins University, McKusick-Nathans Institute of Genetic Medicine

Published in Gene Therapy Weekly, December 25th, 2008

Investigators publish new data in the report 'Circular reasoning: microRNAs and cell-cycle control.' "MicroRNAs (miRNAs) have attracted considerable attention because of their important roles in development, normal physiology, and disease states including cancer," researchers in the United States report.

"Recent studies have identified specific miRNAs that regulate the cell cycle and have documented that the loss or gain of miRNA-mediated cell-cycle control contributes to malignancy. miRNAs regulate classic cell-cycle control pathways by directly targeting proteins such as E2F transcription factors, cyclin-dependent kinases (Cdks), cyclins and Cdk inhibitors. Moreover,...

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