Cytomegalovirus
Researchers at University of Toulouse target cytomegalovirus
Published in Gene Therapy Weekly, December 25th, 2008
"Human CMV (HCMV) is a ubiquitous beta-herpesvirus which has developed several mechanisms of escape from the immune system. IFN-gamma-induced signaling relies on the integrity of the JAK/STAT pathway which is regulated by phosphorylation steps and leads to nuclear translocation of tyrosine-phosphorylated STAT1 (STAT1-P-Tyr), and its binding to IFN-gamma activation site sequences of IFN-gamma-inducible promoters," scientists writing in the Journal of Immunology report.
"Activation of those promoters leads to the expression of genes involved in the immune response and in the antiviral effects of IFN-gamma. Src homology region 2 domain-containing phosphatase 2...
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Source: Gene Therapy Weekly (2008-12-25)
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