Gene Therapy

Investigators at RIKEN target gene therapy

Published in Gene Therapy Weekly, December 25th, 2008

According to recent research from Yokohama, Japan, "RNA-directed DNA methylation (RdDM) is a process in which 24 nucleotide (nt) small interfering RNAs (siRNAs) guide de novo cytosine methylation in the homologous genomic DNA region. Of several factors involving 24 nt siRNA accumulation, RNA-dependent RNA polymerase 2 (RDR2) is a key component. because accumulation of 24 nt siRNA disappears in the Arabidopsis rdr2 mutant."

"Here, we compared expression profiles among wild-type, rdr2-1 and ddc (drm1drm2cmt3), DNA methyltransferase triple mutant, using a whole genome tiling array to identify the candidate genes directly downregulated by RdDM-related 24 nt siRNAs. Of the...

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Source: Gene Therapy Weekly (2008-12-25)

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